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Junichi Kawakami Selected Research

Cytochrome P-450 CYP3A

8/2022Stereoselective interaction of tolvaptan with amiodarone under racemic metabolic impact by CYP3A5 genotypes in heart failure patients.
4/2020Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients.
7/2019Relationships between concomitant biologic DMARDs and prednisolone administration and blood tacrolimus exposure or serum CYP3A4/5-related markers in rheumatoid arthritis patients.
7/2019Relationships between endogenous CYP3A markers and plasma amlodipine exposure and metabolism in early postpartum and non-peripartum women with hypertension.
5/2018Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients.
12/2016Relationships between oxycodone pharmacokinetics, central symptoms, and serum interleukin-6 in cachectic cancer patients.
6/2016Relationship between the plasma fentanyl and serum 4β-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain.
5/2015ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis.
1/2015[Interindividual variation of pharmacokinetic disposition of and clinical responses to opioid analgesics in cancer pain patients].
1/2015[Clinical pharmacology and pharmacoepidemiology for medication safety in clinical settings].
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Junichi Kawakami Research Topics

Disease

24Neoplasms (Cancer)
01/2022 - 01/2004
7Cachexia
01/2022 - 10/2012
7Cancer Pain
06/2016 - 01/2004
4Pain (Aches)
01/2019 - 01/2015
4Nausea
05/2018 - 01/2012
4Vomiting
05/2018 - 01/2012
4Body Weight (Weight, Body)
07/2017 - 01/2013
3Heart Failure
08/2022 - 01/2019
3Inflammation (Inflammations)
01/2022 - 02/2015
3Head and Neck Neoplasms (Head and Neck Cancer)
03/2021 - 11/2017
3Rheumatoid Arthritis
07/2019 - 04/2011
2Systemic Lupus Erythematosus (Libman-Sacks Disease)
07/2017 - 01/2011
2Birth Weight (Birth Weights)
07/2017 - 05/2015
2Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced)
12/2015 - 05/2015
2Critical Illness (Critically Ill)
01/2015 - 10/2013
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022
1Renal Cell Carcinoma (Grawitz Tumor)
01/2022
1Exanthema (Rash)
01/2021
1Atrial Fibrillation
06/2020
1Rotator Cuff Injuries
06/2020
1Hypertension (High Blood Pressure)
07/2019
1Lung Diseases (Lung Disease)
01/2019
1IGA Glomerulonephritis (IGA Nephropathy)
01/2019
1Bacterial Vaginosis
07/2017
1Sleepiness
12/2016
1Lung Neoplasms (Lung Cancer)
05/2015
1Multiple Myeloma
10/2014
1Mycoses (Diseases, Fungus)
01/2013
1Hypoalbuminemia
10/2012
1Nutrition Disorders (Nutritional Disorders)
10/2012
1Rupture
08/2012
1Tendinopathy (Tendonitis)
08/2012
1Testicular Neoplasms (Testicular Cancer)
04/2012
1Intracranial Hemorrhages (Intracranial Hemorrhage)
02/2012

Drug/Important Bio-Agent (IBA)

14Cytochrome P-450 CYP3AIBA
08/2022 - 11/2011
7Oxycodone (Oxycontin)FDA LinkGeneric
12/2016 - 11/2011
5Cytochrome P-450 CYP2D6 (CYP2D6)IBA
03/2021 - 11/2011
4Tramadol (K315)FDA LinkGeneric
03/2021 - 01/2016
4Opioid Analgesics (Opioids)IBA
10/2019 - 10/2012
4Pharmaceutical PreparationsIBA
11/2018 - 01/2004
4Fentanyl (Sublimaze)FDA LinkGeneric
06/2016 - 01/2012
3TolvaptanFDA Link
08/2022 - 01/2019
3Interleukin-6 (Interleukin 6)IBA
01/2022 - 12/2016
3Amlodipine (Norvasc)FDA LinkGeneric
07/2019 - 05/2015
3Tacrolimus (Prograf)FDA LinkGeneric
07/2019 - 04/2011
3Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
11/2018 - 01/2013
3AntiemeticsIBA
05/2018 - 01/2012
3Mycophenolic Acid (Cellcept)FDA LinkGeneric
07/2017 - 12/2008
3GlucuronidesIBA
07/2017 - 12/2008
3noroxycodoneIBA
12/2016 - 11/2011
2Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2008
2Cetuximab (Erbitux)FDA Link
01/2021 - 11/2017
2Aprepitant (Emend)FDA Link
01/2021 - 01/2013
2Pregabalin (Lyrica)FDA Link
10/2019 - 10/2016
2Prednisolone (Predate)FDA LinkGeneric
07/2019 - 01/2019
2Prochlorperazine (Compazine)FDA LinkGeneric
05/2018 - 02/2014
2Narcotics (Narcotic Analgesics)IBA
01/2015 - 01/2004
2Linezolid (Zyvox)FDA Link
01/2015 - 10/2013
2Analgesics (Analgesic Drugs)IBA
01/2015 - 01/2015
2TabletsIBA
10/2012 - 11/2011
2Tissue Plasminogen Activator (Alteplase)FDA Link
02/2012 - 10/2009
2Matrix Metalloproteinases (MMPs)IBA
02/2012 - 10/2009
1Amiodarone (Amiodarona)FDA LinkGeneric
08/2022
1Immunoglobulin G (IgG)IBA
01/2022
1NivolumabIBA
01/2022
1ErbB Receptors (EGF Receptor)IBA
01/2021
1Adrenal Cortex Hormones (Corticosteroids)IBA
01/2021
1edoxabanIBA
06/2020
1SodiumIBA
04/2020
1Biological ProductsIBA
07/2019
1Antirheumatic Agents (DMARD)IBA
07/2019
1DenosumabFDA Link
02/2019
15-diazoimidazole-4-carboxamideIBA
01/2019
1Dacarbazine (DIC)FDA LinkGeneric
01/2019
1Rifampin (Rifampicin)FDA LinkGeneric
01/2019
1Cytochrome P-450 CYP2C19IBA
05/2018
1ProlactinIBA
05/2018
1Complement System Proteins (Complement)IBA
07/2017
1Chloramphenicol (Chloromycetin)FDA Link
07/2017
1Oxidoreductases (Dehydrogenase)IBA
07/2017
1InosineFDA Link
07/2017
1CytokinesIBA
12/2016
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2016
1Erlotinib Hydrochloride (CP 358,774)FDA Link
05/2015
1TriazolesIBA
02/2015
1GlucocorticoidsIBA
02/2015
1Bortezomib (Velcade)FDA Link
10/2014
1Dexamethasone (Maxidex)FDA LinkGeneric
10/2014
1Methicillin (Metin)FDA Link
10/2013
1Oxymorphone (Numorphan)FDA LinkGeneric
08/2013
1hydroxide ionIBA
01/2013
1Cisplatin (Platino)FDA LinkGeneric
01/2013
1BilirubinIBA
01/2013
1Acute-Phase Proteins (Acute-Phase Protein)IBA
10/2012
1FluoroquinolonesIBA
08/2012
1PlatinumIBA
04/2012

Therapy/Procedure

4Therapeutics
07/2017 - 04/2012
3Drug Therapy (Chemotherapy)
01/2013 - 01/2012
1Conservative Treatment
06/2020
1Intravenous Infusions
01/2019